Antitumor effects of octyl gallate on hypopharyngeal carcinoma cells
Trang NTK, 유훈,
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( Trang NTK ) - Chosun University College of Dentistry Department of Pharmacology and Dental Therapeutics
유훈 ( Yoo Hoon ) - Chosun University College of Dentistry Department of Pharmacology and Dental Therapeutics
Abstract
The antitumor effects of octyl gallate (OG) were investigated on FaDu human hypopharyngeal squamous carcinoma cells. At various concentrations, OG inhibited the proliferation of FaDu cells by suppressing cell cycle regulators and induced apoptosis by activating caspase 3 and its downstream poly (ADP-ribose) polymerase, thereby damaging DNA. Immunoblotting demonstrated that OG significantly suppressed the expression of integrin family proteins (integrin α4, αv, β3, β4), hindering cell adhesion. The reduced expression of integrins subsequently mediated the mitogenactivated protein kinase signaling pathway to stimulate the activation of extracellular signal-regulated kinases and c-jun N-terminal kinases, leading to apoptosis. Thus, OG demonstrated antitumor activity on hypopharyngeal squamous carcinoma cells by suppressing cell proliferation and inducing apoptosis.
키워드
Pharyngeal squamous cell carcinoma; Octyl gallate; Apoptosis; Mitogen-activated protein kinase signaling pathway; Integrins
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